Title : Cadmium - associated differential methylation throughout the placental genome : epigenome - wide
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Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes
Epidemiological studies suggest that a father's diet can influence offspring health. A proposed mechanism for paternal transmission of environmental information is via the sperm epigenome. The epigenome includes heritable information such as DNA methylation. We hypothesize that the dietary supply of methyl donors will alter epigenetic reprogramming in sperm. Here we feed male mice either a fola...
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Epigenetics can be loosely defined as the study of cellular "traits" that influence biological phenotype in a fashion that is not dependent on the underlying primary DNA sequence. One setting in which epigenetics is likely to have a profound influence on biological phenotype is during intrauterine development. In this context there is a defined and critical window during which balanced homeosta...
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Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to determine changes to the epigenome in a unique cohort of maternal blood DNA from 11 pregnant women prior to GDM development relative to matched contro...
متن کاملGenome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses
OBJECTIVE Previous studies have shown that differential DNA methylation is associated with SLE susceptibility. How DNA methylation affects the clinical heterogeneity of SLE has not been fully defined. We conducted this study to identify differentially methylated CpG sites associated with nephritis among women with SLE. METHODS The methylation status of 428 229 CpG sites across the genome was ...
متن کاملArsenic and the Placental Epigenome: Unlocking the Secrets of Prenatal Exposure
Experts suspect that epigenetic changes such as DNA methylation may be involved in adverse health effects associated with fetal arsenic exposure. Previous studies have investigated associations between arsenic exposure and DNA methylation in adult and umbilical cord blood cells.1,2,3 Now researchers present an extensive epigenome-wide analysis of placental DNA methylation in relation to fetal a...
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تاریخ انتشار 2017